A study from the Norwegian University of Science and Technology (NTNU) found that Janus kinase (JAK) inhibitors — a class of anti-inflammatory drugs — can suppress a key part of the immune response, potentially allowing viruses like influenza and COVID-19 to replicate and spread more easily.

JAK inhibitors are used globally for conditions like rheumatoid arthritis, psoriatic arthritis, ulcerative colitis and atopic dermatitis.

The researchers say these drugs block an important immune response known as Type I interferon (IFN) signalling, which helps infected cells sound the alarm to neighbouring cells, slowing viral spread and giving the body time to mount a broader defence.

In a video interview with CTVNews.ca on Monday, NTNU researcher and study co-author Denis Kaynov compared the body’s layered immune response to a race with hurdles.

“These inhibitors remove the first line of hurdles — our innate immune defences — allowing viruses to run faster,” he said. “Without that early delay, the adaptive immune system doesn’t have time to respond properly, which increases the risk that the virus spreads rapidly from cell to cell and organ to organ.”

The researchers used a range of human cell types, including lung, eye and brain cells. Kaynov says the team later moved to organoids — simplified lab-grown mini-organs — to mimic the behaviour of full organs more accurately.

While JAK inhibitors are effective in controlling chronic inflammatory conditions, Kaynov says they may leave patients vulnerable if they become infected with a virus.

“If you’re on this kind of medication and get an infection like the flu, the virus could spread much more easily in the body,” he said. “It’s important to consult your physician if you suspect an infection while taking these drugs.”

Although the research remains in early stages, one infectious diseases specialist says the findings are worth noting.

Bogoch says the broader risks of JAK inhibitors are already well known.

It’s well established that if you take these meds you are more susceptible to bacterial infections- therefore viral vulnerability is not a surprise

“They’re not like taking acetaminophen,” he said. “There’s a well-established link to higher susceptibility to infections — especially bacterial ones — so it’s not entirely surprising that viral vulnerability is also being investigated.”

Bogoch emphasized that while the research doesn’t call for immediate clinical changes, it does raise useful questions about drug safety, especially for older adults or patients with multiple health conditions.

Stocks fall as Bessent states no deal on China Tariff Cuts

Dow trims gain, S&P 500 and Nasdaq retreat from session highs as traders digest Bessent comments on tariffs and Powell; Tesla shares bounce

U.S. stocks were off the session’s highs after Treasury Secretary Scott Bessent told reporters there was no unilateral offer from Trump to cut China tariffs.

Still erratic. I’m seriously thinking stock market manipulation.

From earlier

My opinion: Trump believed American clout, globally, was more substantive then it actually is.

Trump Floats ‘Substantial’ China Tariffs Cuts in Trade Deal

President Donald Trump said he plans to be “very nice” to China in any trade talks and that tariffs will drop if the two countries can reach a deal, a sign he may be backing down from his tough stance on Beijing amid market volatility.
“It will come down substantially but it won’t be zero,” Trump said Tuesday in Washington, following earlier comments from Treasury Secretary Scott Bessent that the standoff was unsustainable. Trump added that “we’re going to be very nice and they’re going to be very nice, and we’ll see what happens.”

Trump also said he didn’t see the need to “play hardball” with Chinese leader Xi Jinping and that during discussions he wouldn’t raise Covid-19 — an issue that is politically sensitive in Beijing. The White House recently launched a website that suggested the virus came from a lab in China, irking the nation’s diplomats.

Covid-19 is a sensitive issue in Beijing, because, in my opinion, it was a biological attack on China. Yes, I’d written previously about this explaining why this is my belief

Foreign Ministry spokesman Guo Jiakun said “the door for talks is wide open,” at a regular press briefing in Beijing on Wednesday, reiterating that trade wars don’t have any winners. While Trump has repeatedly sought to get Xi on the phone, China wants the two sides to work out the contours of an agreement before the leaders speak.

original url

http://pennyforyourthoughts2.blogspot.com/2020/05/covid-1984-lockdown-is-planetary.html

As was written at that time

Covid-1984 Lockdown Is a Planetary Psychological Experiment- The End Will Not Justify The Means

Sacrificed in the Name of Covid- The End Will Not Justify the Means

Continuing…  

As my readers know the mass psychological experiment has not applied to:

 Doug Ford

• Doug Yahoo Ford is at it again
• Premier Dougie Yahoo Ford- Hit the Cottage Easter Week end! No Lockdown for yet another Covid Hypocrite

Justin Trudeau. Elizabeth May, Scheer and company

• May, Scheer and Trudeau: Pandemic. What Pandemic?

 Nor did it apply to the man who brought this global insanity down on us all. With his cooked numbers.
Who had his married lover over, on more then one occasion, despite the lockdowns.  After testing positive for Covid-19. While in isolation. Social distancing did not take place.

Neil Ferguson:

• Mathematics of Life and Death – The Trouble With  Modelling Epidemics”…
• Coronavirus: Top Government Scientist Neil Ferguson (tested positive for Covid) resigns from SAGE after breaking lockdown rules 

*Covid Lockdown is the world’s biggest psychological experiment- And we will pay the price

https://www.weforum.org/agenda/2020/04/this-is-the-psychological-side-of-the-covid-19-pandemic-that-were-ignoring/?fbclid=IwAR0NgSFAkHG-2_MWR33RGrplhmcbHnpOYz1pf8UTjH0sE1pmLyPuNE-j954

With some 2.6 billion people around the world in some kind of lockdown, we are conducting arguably the largest psychological experiment ever;

Doesn’t matter to the real covidiots

“This will result in a secondary epidemic of burnouts and stress-related absenteeism in the latter half of 2020;

Currently, an estimated 2.6 billion people – one-third of the world’s population – is living under some kind of lockdown or quarantine. This is arguably the largest psychological experiment ever conducted.

In short, and perhaps unsurprisingly, people who are quarantined are very likely to develop a wide range of symptoms of psychological stress and disorder, including low mood, insomnia, stress, anxiety, anger, irritability, emotional exhaustion, depression and post-traumatic stress symptoms. Low mood and irritability specifically stand out as being very common, the study notes.

In China, these expected mental health effects are already being reported in the first research papers about the lockdown.

In cases where parents were quarantined with children, the mental health toll became even steeper. In one study, no less than 28% of quarantined parents warranted a diagnosis of “trauma-related mental health disorder”.

Among quarantined hospital staff, almost 10% reported “high depressive symptoms” up to three years after being quarantined. Another study reporting on the long-term effects of SARS quarantine among healthcare workers found a long-term risk for alcohol abuse, self-medication and long-lasting “avoidance” behaviour. This means that years after being quarantined, some hospital workers still avoid being in close contact with patients by simply not showing up for work.

Reasons for stress abound in lockdown: there is risk of infection, fear of becoming sick or of losing loved ones, as well as the prospect of financial hardship. All these, and many more, are present in this current pandemic.”

“In our most recent survey after two weeks of lockdown, the green portion has shrunk to 25% of the population. The “red” part of the population has increased by 10 percentage points to fully 25% of the population.

And we’re in the eighth week of lock down here. Justin Trudeau and Doug Ford excluded.

“These are the people at high risk for long-term absenteeism from work due to illness and burnout. Even if they stay at work, research from Eurofound reports a loss of productivity of 35% for these workers.

In general, we know at-risk groups for long-term mental health issues will be the healthcare workers who are on the frontline, young people under 30 and children, the elderly and those in precarious situations, for example, owing to mental illness, disability and poverty.

All this should surprise no one; insights on the long-term damage of disasters have been accepted in the field of trauma psychology for decades."

It’s doubtful this is a surprise. And much more likely it is desired. It’s long been known that trauma has repercussions. So trauma on a global scale will have mass repercussions.

Link

“There’s a real recognition that the mental health impacts are going to be severe,” said Margaret Eaton.

That Ontario survey also found 42 per cent of Ontario adults reported increasing their use of substances or gambling since the pandemic began.

Given the country was already facing an opioid epidemic before the pandemic, Eaton said, that finding is “a big concern” and that there are resources for people trying to understand if their substance use has become a problem.

The media, alt and main stream, should be ashamed of their heavy handed fear mongering and their role in terrorizing the populace- That these issues would present themselves was knowable. Foreseeable.  Isolation is a huge issue. Joblessness. Family distress. Financial issues. Drug and alchohol use on the rise.
 Handling this situation in a different manner, which could have been done and should have been done would have minimized this impending tsunami of harm and destruction.

‘Cause let’s face the reality the lock downs did nothing to make the elderly or vulnerable safer.

• Canada’s Leads the 14 Nation Pack in Long Term Care Elder Deaths- 82% of Covid Deaths in Long Term Care System
• The ‘Massacre’ of Italy’s Elderly Nursing Home Residents 

So, why my more than 4 year old article?

Telegram- How Covid destroyed our lives.

Not the virus. The brutal over reaction to it. With the damage still obvious to this day

“No shit sherlock”

Lawrence Greenspon does a media scrum after day two of a multi-week trial. Give it a listen!

As we head into day 3 of the trial and the prosecution presents it’s case, cracks in the official narrative are beginning to appear. Which should surprise no one.

The infamous line “not one inch” that had seemingly been attributed to convoy leaders often in tandem with “hold the line” was in all actuality the stance of the Ottawa Police.

We can see that Global News obfuscates what “not one inch” refers to and whose edict that actually was. By making a vague headline they are encouraging their readership to assume this was the stance of the convoy organizers. It was not. It was the stance of Ottawa police higher ups.

Day 2 of ‘Freedom Convoy’ trial hears police were told: ‘Not one inch’

Working with the Police Liaison Team (PLT), Lucas said there were plans to try and move some vehicles from congested intersections like Rideau and Sussex to gaps on Wellington Street.

“

Once I put the proposal through the chain of command, we were given the direction to give them “not one inch,” so that undermined the work of the PLT,”

Lucas told the court that there were no flags on the behaviour of those in the convoys. He referenced positive interactions with police on the route to Ottawa, including obliging with a request to divert the convoy due to a police operation on the route.

Hubby and I protested this tyranny at the local level. Yes, we made signs and froze our buttocks off. There was no choice given the level, the absurd level of abuse and discrimination that was being dished out towards those that didn’t bow to the edicts of a governmental over reach. Canada was a dystopic nightmare. We still have our signs.

Too many lies. Too much abuse. It was and remains to this day a shocking episode in Canada’s history.

https://web.archive.org/web/20210411192744/http://pennyforyourthoughts2.blogspot.com/2021/04/your-mrna-and-cancer-suppression-mrna.html

original url

https://pennyforyourthoughts2.blogspot.com/2021/04/your-mrna-and-cancer-suppression-mrna.html?zx=b47d797ad6e7cfd0

Sunday, April 11, 2021

Your mRNA and Cancer Suppression – mRNA vaccine ‘teaches our bodies to make a protein” ?

On a theme of viruses, vaccines and cancer..

Common Cold Virus Kills Off Cancer- As Do Other Viruses- Interesting!

 To this interesting report:

• In a Twist, Scientists Find Cancer Drivers Hiding in RNA, Not DNA

Most people think of cancer as a disease of disorderly DNA. Changes, or mutations, in the sequence of DNA alter the function of the proteins made from that DNA, leading to uncontrolled cell division.

But between DNA and proteins is another layer of information, called messenger RNA (mRNA), which serves as a crucial link between the two. New research suggests that mRNA itself may carry cancer-causing changes. And, because genetic tests don’t usually look at mRNA, those changes have so far gone undetected by cancer doctors.

“New research suggests that mRNA itself may carry cancer-causing changes.“

From DNA to mRNA

If DNA is the genetic blueprint for life, as is often said, then it’s a fairly cumbersome set of instructions. The information in DNA is encoded in the particular sequence of some 3 billion nucleotide “letters” — varying combinations of A, T, G, and C. Blocks of these letters — genes — are used to make particular proteins, a cell’s main workhorses. But DNA lives in the nucleus of a cell, while proteins are made in the surrounding cytoplasm. To bridge this gap, a cell must first make an RNA copy of a gene’s DNA. This RNA copy, called messenger RNA, is then transported out of the nucleus. It is this mRNA copy that cells read and translate into a protein.

Usually, the mRNA copy is a bit shorter than its DNA precursor. That’s because the useful pieces of information in DNA, called exons, are often separated by blocks of sequences that are not needed. These unnecessary parts, called introns, must be cut out to make a final product. After the introns are removed, the remaining exons are spliced together, not unlike splicing together pieces of film and leaving some on the cutting room floor.  

These findings help explain a long-standing conundrum, which is that CLL cells have relatively few known DNA mutations.

If the mRNA copy doesn’t include all of the exons in a gene or is cut short, then the protein made from that mRNA will also be truncated. It may no longer function properly. And if that protein is a tumor suppressor — one that protects against cancer — then that could spell problems.

What Dr. Mayr and her colleagues, including postdoctoral fellow Shih-Han (Peggy) Lee, graduate student Irtisha Singh, and SKI computational biologist Christina Leslie, found is that many of the mRNAs in cancer cells produce these truncated tumor-suppressor proteins. The changes occur not only in known tumor-suppressor genes but also in previously unrecognized ones.

 “The changes to the mRNA make proteins that are very similar to the proteins that are made when you have a mutation in the DNA that causes a truncated protein to be made,” she says. “In the end, the outcome for the cell is very similar, but how it happened is very different.”

Found: Missing Cancer Mutations

Dr. Mayr’s team looked specifically at chronic lymphocytic leukemia (CLL), a type of blood cancer. A colleague at MSK, Omar Abdel-Wahab, supplied them with blood samples from people with the condition. Using a method that Dr. Mayr’s lab developed to detect these particular mRNA changes, they found that a substantially greater number of people with CLL had an inactivation of a tumor-suppressor gene at the mRNA level than those who had it at the DNA level.

These findings help explain a long-standing conundrum, which is that CLL cells have relatively few known DNA mutations. Some CLL cells lack even known mutations. In effect, the mRNA changes that Dr. Mayr’s team discovered could account for the missing DNA mutations.

Because CLL is such a slow-growing cancer and people with CLL often live for many years, it’s too early to say whether these mRNA changes are associated with a poorer prognosis. 

There are some important differences between the mRNA changes and a bona fide DNA mutation. Most important, the inactivation of tumor suppressors through mRNA is usually only partial; only about half of the relevant protein molecules in the tumor cells are truncated. But in many cases this is enough to completely override the function of the normal versions that are present. And because this truncation could apply to 100 different genes at once, the changes can add up.

Lessons for Cancer Diagnostics

Though Dr. Mayr’s team identified the mRNA changes in CLL, they’re likely not limited to this blood cancer. The team found them in samples of T cell acute lymphocytic leukemia too, for example. Other researchers have found them in breast cancer. Dr. Mayr hopes that scientists will be inspired to explore the significance of mRNA changes in these and other types of cancers.

“Current cancer diagnostic efforts predominantly focus on the sequencing of DNA in order to identify mutations,” Dr. Mayr says. “But our research suggests that changes at the mRNA level might be as frequent.”

In other words, cancer diagnostics may need to change to include these previously unknown cancer drivers.

 If you’ve been paying attention to the way the  experimental covid vaccine is supposed to work, then you are or should be aware, that the vaccine, as claimed by the CDC alters our mRNA

“MRNA vaccines teach our cells how to make a protein—or even just a piece of a protein—that triggers an immune response inside our bodies.”

Keeping in mind there are no long term studies for this vaccine. It was not approved, only authorized for emergency use.

Why bring this post back from more than 2 years ago? mRNA can cause cancer changes. This RNA copy, called messenger RNA, is then transported out of the nucleus. It is this mRNA copy that cells read and translate into a protein. mRNA changes may trigger cancer cells. Noticing cases of cancer, rapid onset and demise being connected to mRNA jab recipients.

Posted by Penny at 10:31 AM

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Labels: big pharma, Covid-1984, health, state sponsored terrorism, technocracy

Admitted in the CTV spin piece

“Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.“

What kind of support? Not mentioned? Obviously it’s financial which is why CTV doesn’t disclose the type and amount of support!

CTV

The report estimates (weasel wording) that vaccine hesitancy affected more than 2.35 million people between March and November 2021.

The report only looked at that nine-month period during the pandemic–

March to November 2021- right at the start of the vaccine rollout. When less people were vaccinated at that time due to logistics and non approval for minors.

This NGO is suspect. As are all NGO’s

No Good Organization– CCA

The Council of Canadian Academies (CCA) is a not-for-profit organization that convenes the best experts in their respective fields to assess the evidence on complex scientific topics of public interest to inform decision-making in Canada.

Who funds this group?

Their “experts” don’t come cheap.

So show me the money trail!

Consider this piece pharma propaganda- The CTV article acknowledges as much and a minimal amount of digging on the NGO would undoubtedly uncover corporate/GAVI financing.

Recall the coverage of the fact that Paxlavoid is yet another EAU experimental medication. And what little is known is nothing to crow about!

https://www.fda.gov/media/155050/download

If you were one of those persons living in reality and you are up on all that information, understanding the problems with the jab and the Paxlavoid. Then the fact that quadruple jabbed, paxlavoid user is feeling extremely unwell won’t come as that big a shocker.

Dr. Anthony Fauci, sometimes dubbed “America’s doctor,” is reportedly feeling extremely unwell after contracting COVID-19 earlier this month.

Fauci has received both initial doses of Pfizer’s COVID vaccine as well as two booster shots, as he advises for people of his age — Fauci is 81.

Fauci has also taken Paxlovid, Pfizer’s antiviral treatment for COVID, and experienced a rebound, following which he decided to take another course of the treatment, even though this is not officially recommended, with the FDA stating that, “There is no evidence of benefit at this time for a longer course of treatment … or repeating a treatment course of Paxlovid in patients with recurrent COVID-19 symptoms following completion of a treatment course.”

Initially, Fauci described his symptoms as “minimal” and expressed his relief at being double-boostered. Speaking during a Foreign Policy global health summit on Tuesday, Fauci said he tested negative for three days in a row after he finished taking Paxlovid but that on the fourth day, he tested positive again, a phenomenon that’s referred to as a “Paxlovid rebound,” and now has said he feels “really poorly.”

Recall this news from just the other day?

In the first 14 weeks of 2022 there were DOUBLE the Covid fatalities of the two preceding years! Think about that FACT. 95 percent vaccination rate- 14 weeks/double the death count of 2020/ 2021 combined

Recently the fact of Ontario, Canada’s mass covid case drop despite masks being largely not worn was mentioned. In spite of the headless chickens in the media squawking endlessly, No masks aligned with a massive fall in cases.

Now we have this piece in the NYT’s

The evidence suggests that broad mask mandates have not done much to reduce Covid caseloads over the past two years

In U.S. cities where mask use has been more common, Covid has spread at a similar rate as in mask-resistant cities. Mask mandates in schools also seem to have done little to reduce the spread. Hong Kong, despite almost universal mask-wearing, recently endured one of the world’s worst Covid outbreaks.

Advocates of mandates sometimes argue that they do have a big effect even if it is not evident in populationwide data, because of how many other factors are at play. But this argument seems unpersuasive.

Unpersuasive because it is not born out by reality. Therefore advocates of mask mandates are coming from a place of unreality. Of delusion.

When you look at the data on mask-wearing — both before vaccines were available and after, as well as both in the U.S. and abroad — you struggle to see any patterns.

Mask mandates do not work. They were and are abusive, divisive and have served to increase societal divide. They were a mode of psychological warfare waged against the populace. Done to terrorize into submission. They did not impede viral spread.

Those are the facts. That is the reality. Anything else is manipulative lying

btw: Weekly update for tomorrow will not be taking place until October 4/21. Instead of October 1/21- 3 day delay for data update.

What you need to know up to and including September 17, 2021

16,090 Total adverse event following immunization reports (0.029% of all doses administered)

PHAC and Health Canada are actively monitoring three ongoing safety signals:

Reported cases of thrombosis with thrombocytopenia syndrome following vaccination with AstraZeneca Vaxzevria/COVISHIELD COVID-19 vaccine. Health Canada has updated the product monograph to include information about these very rare events of blood clots associated with low levels of platelets following immunization.

Up to and including September 17, 2021, there were 81 reports of TTS that met Level 1 to 4 of Brighton

Reported cases of Guillain-Barré Syndrome (GBS) in Canada following AstraZeneca Vaxzevria/COVISHIELD COVID-19 vaccination. Data in Canada indicate a higher number of cases than would normally be expected in the general population. Health Canada has updated the AstraZeneca Vaxzevria/COVISHIELD COVID-19 vaccine product monograph to include information on GBS.

Up to and including September 17, 2021, there are a total of 79 reports of GBS

Up from last weeks high of 76- 3 more persons suffering some sort of paralysis

Reported cases of myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the lining around the heart) following vaccination with COVID-19 mRNA vaccines. Data in Canada now indicate a higher number of cases in younger people (i.e. less than 40 years of age) than would normally be expected in this age group in the general population. Health Canada updated the product monographs for both Moderna Spikevax and Pfizer-BioNTech Comirnaty COVID-19 vaccines to include information around these risks.

Up to and including September 17, 2021, there were 774 reports of myocarditis/pericarditis. Big increase from last weeks high of 718- That’s 774 damaged hearts. Permanently damaged.

• Facial paralysis/Bell’s Palsy following COVID-19 vaccination. Health Canada has updated the product monograph for both Pfizer-BioNTech Comirnaty and Moderna Spikevax COVID-19 vaccines to include information on facial paralysis/Bell’s Palsy.

474 cases has stayed the same, but, will inevitably increase as the lagging data is compiled

• Capillary leak syndrome
  Up to and including September 17, 2021, there have been two reports of capillary leak syndrome

• Deaths

Up to and including September 17, 2021, a total of 191 reports with an outcome of death were reported following vaccination.

Up from last weeks high of 189 The 191 is not credible in the least.

Open Vaers/US data has the death count at 15, 386

Knowing that number is grossly under counted by at least a factor of 5 but likely a factor of 10, suggests to me that Canada’s count is under counted massively.

• As we can see the numbers going back to May 21 have changed yet again! When, if ever, will we get the real data?
  *May 14/21 : Last week was at a combined total of 863. This week the total harm count is 919
  *May 21/21: Total combined harm stood at…. This week the total stands at 729
  *May 28/21 Last week’s count 413. This week 433. Another 20 adverse reactions
  *June 04/21 Last week 482. This week 514
  Every week the adverse effect numbers go up from months ago. How long is it going to take to get anywhere close to knowing the real harm being done? If ever?

It’s always admitted this data is inadequate. Not accurate. Estimated at best. Deceptive, most likely.

*Data notes

The data presented in this report are estimates and may not accurately represent national COVID-19 vaccine adverse events for the following reasons:

There may be delays in receiving reporting forms and processing reporting forms which may contribute to variations in the amount of reports presented weekly. These delays may be due to jurisdictions investigating and reviewing each adverse event prior to submitting the information to PHAC. There are also limitations to reporting practices such as underreporting, missing information, and differing adverse event reporting practices accross jurisdictions in Canada.
Information is collected on individuals for whom an report was submitted, not on the total number of individuals who experience an adverse event as not every adverse event is reported. 

Despite the fact officialdumb keeps adding warnings to the vaxx.. They keep claiming it’s safe and effective. Bullbiscuits. Doesn’t stop the spread of the virus. Breakthrough cases on the rise. Very high adverse reactions. Frightening to consider long term effects. My god people! Did you catch the link in today’s previous post (below) to the WHO?

Like Icarus, are we flying too close to the sun with a DNA Covid Vaxx?

If not, let me drag a snippet that info here-

Several potential safety issues associated with administering plasmid DNA into humans are discussed below:
• The injected DNA taken up by cells of the host may integrate into the host’s chromosomes and cause an insertional mutagenic event.
• The long-term expression of a foreign antigen may result in an undesired immunopathological reaction.
• The use of genes encoding cytokines or co-stimulatory molecules may pose additional risks.
• Antibodies may be formed against the injected DNA itself and these may contribute towards undesired autoimmune reactions.
• The expressed antigen may itself have biological activity.
• Expression of other gene sequences in mammalian or bacterial cells may pose a risk.

Human experimentation on a wide scale. That’s the reality.

You can find last weeks report here.

• Canada’s Weekly Covid Vaccine Injury & Death Report- Jesse Jackson’s Covid?

My hope is to eventually get this all in one location